Matthew D. Zock, CIH and Senior Scientist Keith P. Rickabaugh of RJ Lee Group, Inc. co-authored an article with Scott Soefje of the University of Texas Health Science Center that was published in the March 2011 issue of the Journal of Oncology Pharmacy Practice (JOPP). The article on closed-system transfer devices (CSTDs) is titled “Evaluation of surface contamination with cyclophosphamide following simulated hazardous drug preparation activities using two closed-system products” evaluates and compares the effectiveness of two CSTD products in preventing contamination of pharmacy workplace surfaces.
Handling of chemotherapy drugs has been recognized since the 1970s as a potential health hazard to workers. NIOSH and The United States Pharmacopeia’s General Chapter 797 (USP 797) recommend using a closed-system transfer device to minimize occupational exposures to antineoplastic and other hazardous drugs. Two separate trials simulating hazardous drug compounding using a chemotherapy drug were performed with two different closed-system products. Prior to the trial and following each trial, wipe samples were collected from the work area surfaces and compared to determine the effectiveness of each closed-system product. Results indicated that further study and statistical analyses are needed to investigate the containment effectiveness of the products in a controlled setting.
Mr. Zock has more than 10 years professional experience in industrial hygiene, EH&S and technical consulting and has conducted numerous studies of hazardous drug surface contamination in hospital pharmacies and treatment areas. Mr. Rickabaugh has more than 15 years of experience in providing technical consulting and is Director of Materials and Analytical Services at RJ Lee Group.